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Has Eli Lilly Found a Cure for Alzheimer’s Disease?
Published
3 years agoon
As of today, there’s no proven cure yet for Alzheimer’s disease.
Alzheimer’s is a degenerative brain disease caused by multiple brain changes due to cell damage. It is one of the most common causes of dementia. Today, at least 50 million people across the globe are believed to be living with Alzheimer’s disease.
In the US alone, over 5.8 million people suffer from Alzheimer’s disease. It is predicted that by 2050, 13.8 million Americans aged 65 above could be living with Alzheimer’s unless scientists develop new treatments to prevent or cure.
Eli Lilly and Co. (LLY.N) announced on June 24, 2021, that it would seek accelerated approval from the USFDA for its Alzheimer’s candidate. It happened weeks after a rival drug from Biogen Inc. (BIIB.O) won the agency’s support for a similar regulatory pathway. Following the announcement, Lilly’s shares rose to over 8%, while Biogen went down to nearly 5%.
A drug developed by Biogen called Aduhelm was approved under the FDA’s accelerated approval program. The said program permits certain medicines on the market earlier if proven based on pieces of evidence to be beneficial to patients. However, such approvals are still subject to follow-up studies to verify if the drugs work as intended.
About Eli Lilly and Co.
Eli Lilly and Company is a US-based drug manufacturing company. The company develops several human pharmaceutical product sectors. Established in 1876 and was named after Colonel Eli Lilly, a pharmaceutical chemist, and veteran of the American Civil War.
Eli Lilly’s main office is located in Indianapolis, Indiana. Eli Lilly has offices in 18 counties, but their products are sold in approximately 125 countries. It is the first company to mass-produce the polio vaccine and insulin. It is currently the biggest manufacturer of psychiatric medications and produces Prozac, Dolophine, Cymbalta, and Zyprexa.
USFDA criticized for the approval of Biogen’s Aduhelm
USFDA faced rising criticism over the mentioned Alzheimer’s drug approval. Based on a report from Reuters, Biogen’s Aduhelm was approved based on the evidence that it can reduce brain plaques, a possible contributing cause of Alzheimer’s. There was no proof that it slowed down the progression of the disease. In addition, experts said that the regulatory agency ignored the recommendations of its third-party advisors, who believed that Biogen did not provide enough evidence of Aduhelm’s benefit.
Earlier, Biogen claimed that one of the two vital studies revealed a significant benefit in slowing cognitive and functional deterioration amongst Alzheimer’s patients. Sad to say, the second trial showed that the drug only helped patients who were provided with a high dose for at least 10 months.
Eli Lilly’s Donanemab Clinical Trial
The company said they would apply for USFDA approval based on data from a mid-stage, 272-patient clinical trial, which showed that Donanemab slowed the rate of decline in patients’ cognition and function. Like Adulhelm, the candidate from Eli Lilly, Donanemab, is designed to remove bunches of a hallmark Alzheimer’s protein known as beta-amyloid from the brain.
According to experts and analysts, the findings help prove that plaques play an important role in Alzheimer’s. Donanemab targets a type of beta-amyloid called N3pG which can be cleared, allowing precise treatment of patients until their plaques are removed.
Patients who participated in the study stopped receiving monthly infusions of the drug. They were also switched to placebo once their brain plaques achieved levels witnessed in healthy persons. Accordingly, the process took just a few months for some patients.
Mr. Daniel Skovronsky, Lilly’s chief scientific officer, told Reuters that the study illustrates that the presence of amyloid is an essential factor in the progression of Alzheimer’s disease. He also said that the results show that additional strategies are needed to fight the disease ultimately.
Alzheimer’s is not just memory loss. Alzheimer’s is fatal. Eli Lilly said that the mid-stage trial met its primary goal of proving a significant change. The result of the secondary objectives of the clinical trial measured that cognition and function were positive, though not all of them reached statistical significance.
Current Studies on the Drug
Eli Lilly continues studying the drug with a second trial among 500 patients.
Lilly and Biogen are among the large pharmaceutical companies finding a cure for Alzheimer’s disease. Any Alzheimer’s treatment that can halt the progression of the disease is a multi-billion-dollar product. Sadly, the field is beset by more than a hundred failures, including those that target beta-amyloid.
Eli Lilly begins a quick USFDA review for Alzheimer’s candidate drug, Donanemab, and a head-to-head test against its rival Aduhelm. The search for medicine against Alzheimer’s continued as Eli Lilly secured an accelerated FDA review for Donanemab.
Despite issues of Biogen, Eli Lilly is hopeful that they will succeed in this endeavor. Along with the rolling submission news, the Indianapolis Big Pharma also presented plans of a crucial Phase 3 trial known as Trailblazer-Alz 4 as a one-on-one test comparing Donanemab to Aduhelm. The project aims to assess who among the candidates is superior in removing brain amyloid plaque in the early-onset Alzheimer’s disease.
Initial results from the study would be available in the second half of 2020, according to Mr. Skovronsky. The application will commence this year and have continued monitoring by the market and the FDA. If the Donanemab beats Aduhelm and Eli Lilly can be keen on pricing, they can succeed in a more market-ready Alzheimer’s treatment.
What’s Next for Eli Lilly and Co.?
The head-to-head trial of the two competing firms may not arrive at a critical question encountered by all the companies working on Alzheimer’s rehabilitation. Do they work? Mr. Skovronsky said the test would be simple, focusing on removing plaque on the brain instead of clinical efficacy.
If we trust that plaque lowering is the appropriate alternative, then this question would be answered in the next 12-18 months, Mr. Skovronsky concluded.
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10 Design Pickle Alternatives to Get Even Better Designs
Published
6 months agoon
May 1, 2024Looking for an alternative to Design Pickle? We have just the list for you.
Design subscriptions are now popular amongst entrepreneurs, small businesses, and even corporate giants. The model is simple: you pay a flat monthly rate and get as much design help as you need – websites, custom illustrations, branding assets, ad design, packaging design, and more.
In a world where traditional agencies charge exorbitant fees and the freelance market is hit or miss, more and more brands are opting for this simple, comprehensive design solution. If you have no time to vet freelancers for every project and no budget for a team of in-house designers, this might be a perfect fit for you.
We went ahead and ranked the top unlimited graphic design companies in the industry that rival Design Pickle.
1. Penji
One of the top competitors of Design Pickle is Penji. This is because Penji offers a very comparable gamut of design services at a lower price point. Penji is one of the biggest unlimited graphic design providers in the industry and has consistently received strong reviews (4.8 average) across sites like Trustpilot, Facebook, and Google.
Penji stands out for its responsive customer service and exceptional designers. Their user-friendly platform makes requesting designs simple, allowing users to easily navigate and communicate with their designer. Each tier of Penji’s subscription is tailored to cater to diverse requirements, be it ad creatives, presentation designs, or motion graphics, ensuring various types of clients get the most value for their dollar.
Why we recommend:
– Designers are matched to your project based on their skillset and your specific need
– Penji offers logo designs, illustrations, and UX/UI for apps & websites
– Their customer support is responsive and quick
– There are over 100 design services to choose from
– You get access to a Project Manager or Art Director at higher tiers
Price: $499-$1497
2. Superside
Superside is a well-known company offering scalable design solutions that are suitable for brands of various sizes, from startups to large enterprises. Their services are priced significantly higher than other graphic design services, so they’re best for companies with larger budgets.
Why we recommend:
– You get access to a dedicated design team
– They offer static and motion ad creative for testing ads
– They’ve worked with big brands like Google, Shopify, and Meta
– Superside’s video production quality is top notch
– If you run out of design credits, you can order more at any tier
Price: $5,000-$13,000 (50-150 credits)
3. Fiverr
Fiverr is the only non-subscription service on the list, but many people don’t realize that individual freelancers can now offer subscriptions on Fiverr. The platform is famous for its wide range of freelance services at an incredibly affordable price. Typically, Fiverr matches you with a freelancer for a one-off project like a logo or website design. You might be able to get a logo for just $15, but in-demand designers might charge you $1000-2000 for a website.
Why we recommend:
– Fiverr manages the relationship, making financial transactions safer
– There’s no need to waste time or money hiring a full-time designer if you don’t need one
– You can choose from hundreds of designers to find the exact style you like
Price: varies widely (You might be able to get a logo for just $15, but in-demand designers might charge you $1000-2000 for a website.)
4. Flocksy
Flocksy is another unlimited graphic design service much like Penji and Superside. The company has a decent reputation online and offers comparable services to other design subscriptions. However, there are two major differences: They offer copywriting and video editing. Flocksy gives you access to an easy-to-use platform for submitting requests, tracking progress, and communicating with the creative team.
Why we recommend:
– Flocksy offers video editing and copywriting in their two highest tiers
– You can get Zapier integrations at every tier if desired
– They offer a 14-day money back guarantee if you choose not to continue
Price: $499-$1695
5. ManyPixels
Manypixels is another growing company that offers a similar service to Design Pickle at a comparable price. The company boasts clients like Teachable and Buffer. You can also get free stock assets from Manypixels, which is a nice perk to complement unlimited designs.
Why we recommend:
– Have an intuitive online platform for communication and storing files
– Pay monthly, quarterly, or yearly (save 10% quarterly, 20% yearly)
– Get a designated designer at the highest tier and collaborate in real-time
Price: $549-$1299
6. Kimp
Kimp is similar to other graphic design subscription services but offers unique pricing tiers. Unlike its competitors, Kimp provides both design and video services without requiring separate plans, ensuring a comprehensive creative solution. Clients also benefit from dedicated design and video teams, ensuring consistent quality and brand alignment across all projects.
Why we recommend:
– Choose only what you need: video, graphics, or both
– A speedy 2-4 day turnaround for video projects
– Kimp offers a 2-month discount as you’re getting started
– Get free stock video, audio and images in their top tier
Price: $599-$995
7. DesignJoy
DesignJoy came along just two years after Superside and have similar price range. They’re a big name in the design industry because they’ve worked with brands like Google and Verizon. Their standard tier allows you the manage unlimited brands along with unlimited users and stock photos.
Why we recommend:
– Webflow development available on both tiers
– Unlimited users on their higher tier
– You can refer a friend and get 5% monthly recurring commissions
Price: $4,995-$7,995
8. Delesign
Delesign has existed since 2017 and has leveled up its services each year. For the same price as many others on the list, Delesign also offers 2D animation videos. We’re not sure of the quality, length, or requirements, but this is a great bonus for brands that want to incorporate it.
Why we recommend:
– 2D animation videos are included in the package
– Guarantees quick turnaround times for initial drafts: 24 to 48 hours
– Zapier and Slack integrations on every plan
Price: $599 – $1799
9. No Limit Creatives
Roughly the same age as Delesign, No Limit Creatives is another design services that has grown in notoriety in recent years. They’re unique in that they offer 4 tiers for graphic design while most offer 3. Like Kimp, they have a tier for graphics and video, and each tier allows a different number of requests at a time. Their lowest price tier uses design credits much like Superside’s model.
Why we recommend:
– Get a dedicated design team on 3 out of 4 tiers
– A whopping 3 requests at a time are available at the highest tier
– The highest tier also offers real-time communication through Slack
– NLC provides video editing and video creation
Price: $499-1499
10. Kapa99
Kapa99 is a small company but they compete well with larger competitors like Design Pickle. They’ve been around since 2014 and thus have had plenty of time to perfect their craft. Kapa’s tiers are split into just two: Business and Business Express. Express offers speedier delivery for clients with more pressing deadlines.
Why we recommend:
– They offer a significant discount for the first two months of your subscription
– There’s no limit to how many ‘active tasks’ you can have on your dashboard
– Native Adobe source files
– Canva file delivery
Price: $499-$999
Top Stories
10 Environmental Organizations and Nonprofits To Save the World
Published
10 months agoon
January 25, 2024Making positive changes in our lifestyle is a powerful way to tackle important issues. Supporting charities is another great way to help the environment, make a difference, and build a better future. In this light, now is a great opportunity for government, business, and individuals to back environmental nonprofits. Here are ten groups working for a sustainable future that you can support. Get started by choosing an organization that really connects with your values.
1. World Wildlife Fund for Nature
This Swiss-based NGO focuses on conserving nature and reducing human environmental impact. Acknowledged for its work with endangered species, WWF has expanded its mission to cater to specific animals and landscapes and to more significant issues that affect them.
WWF partners with governments, businesses, and other environmental organizations to implement policies and programs protecting wildlife, nature, and the global climate.
How to get involved: Sign up to take action on a particular campaign, adopt a species, participate in one of its partner-led conservation tips, or get updates on its causes.
2. One Percent For the Planet
One Percent For the Planet is a global convergence of businesses, environmental organizations, and individuals working together for a healthy planet. Founder Yvon Chouinard (also Founder of Patagonia) started the organization to bring ” dollars and doers” together to create change. Member brands commit one percent of their profits to support environmental action. The organization ensures those donations go to trusted nonprofits involved in wildlife and nature conservation, reforestation, ocean cleanups, and other environmental efforts.
How to get involved: Become a business member and donate 1% of your annual sales directly to One Percent for the Planet’sPlanet’s environmental partners network.
3. Fashion Revolution
Fashion Revolution is a worldwide movement bringing people and brands together towards creating a safer, cleaner, and fairer fashion industry. Founded after the Rana Plaza collapse in 2013, Fashion Revolution believes that collaboration across the value chain is the best way to transform the industry radically. It works with global coordinators to host events every year for an entire week in April to inspire consumers and brands to take a closer look at how and by whom their clothes were made.
How to get involved: Participate in the #WhoMadeMyClothes campaign all year round, especially during Fashion Revolution Week, which takes place annually in late April.
4. Earthjustice
Earthjustice attorneys support various significant environmental policies, such as the Endangered Species Act and the Clean Air Act. Earthjustice works with activists, national politicians, international policymakers, and individuals to protect and strengthen laws to benefit people and a healthy planet.
How to get involved: Make a one-time or monthly donation and support essential campaigns.
5. Natural Resources Defense Council (NRDC)
The Natural Resources Defense Council aims to safeguard the Earth, including its people, plants, and animals. Founded in the 1970s by a team of law students and attorneys, NRDC is now a membership-based organization that works with lawyers, activists, scientists, businesses, and individuals to identify problems and formulate sustainable solutions. NRDC also ensures that everybody has the right to clean air, clean water, and healthy wild spaces.
How to get involved: Make a one-time or monthly donation, or add your voice to essential campaigns.
6. Conservation International
Conservation International (CI) aims to protect the Earth to provide us with fresh water, adequate food, sustainable livelihood, and a stable climate. CI works with governments, business leaders, and individuals to implement doable solutions to climate change-related problems. In its 30 years of operation, the organization has successfully protected more than 601 hectares of land, marine, and coastal areas.
How to get involved: A $25 donation here will protect one acre of forest. Other ways to get involved with CI include:
- Subscribing to receive conservation news and calls to action in your inbox.
- Taking the “I Need Nature and Climate Action Pledge.”
- Reading their tips for greener living.
7. Rainforest Alliance
The Rainforest Alliance is a nonprofit working to create a better future for people and the Planet. They offer a certification program for brands selling rainforest-friendly products. They also work alongside activists, businesses, small farmers, and forest communities to drive positive social, environmental, and economic change across forest landscapes.
How to get involved: Promote their frog seal while shopping for rainforest-dependent products such as tea, coffee, chocolate, and paper. Environment-conscious travelers can even opt for Rainforest Alliance-certified hotels and tours worldwide.
8. Greenpeace
Greenpeace is an international environmental organization whose mission is to create a green, peaceful, and ecologically diverse world. It relies on its membership of activists, students, educators, scientists, and environmentalists to investigate issues and solutions, lobby governments, and show up for actions against climate change.
How to get involved: Join a local group of activists and follow along with Greenpeace’s journalism site, Unearthed. Donations are also welcome.
9. Lonely Whale Foundation
Lonely Whale Foundation works with businesses and entrepreneurs to develop environmental business models, gets involved in communities to educate the next generation better, and initiates global movements to address plastic pollution in our oceans.
How to get involved: Check out current campaigns to get involved in or donate.
10. 350.org
With members in over 180 countries, 350.org uses social media campaigns, grassroots organizations, and collective public action to support clean energy solutions. Its primary objectives are to reduce carbon footprint, help build a zero-carbon economy, and make governments accountable for limiting their emissions.
How to get involved: Join a local group near you and support the initiatives they are working on. You can also start your own or donate if you are far from an existing group.
Top Stories
Up in the Air: The Dark Side of Balloon Releases
Published
10 months agoon
January 11, 2024While balloons bring momentary delight in celebrations and events, this tradition poses ecological challenges we often forget. They are harmful to wildlife, marine ecosystems, natural resources, and even toddlers. Balloons filled with helium look so pretty in the sky. However, they can’t stay afloat for so long. Each of these balloons pops and plunges to the earth, turning into trash. This is why balloon releases should be banned.
How the Tradition of Balloon Releases Harms the Environment
Releasing balloons has become a customary practice in local events, including schools, weddings, and memorials, with origin tracing back to the 1940s. We acknowledge the emotional significance of traditions, like those we’ve seen in sporting events with fireworks, marching bands, and cool mascots. However, it is becoming more evident that haphazard balloon releases have several harmful implications for the environment.
Insert image: The Indy 500 balloon launch
Caption: The Iconic Indianapolis 500 Balloon Launch in May 2019. Source: speedsport.com
In May 2019, The Indianapolis Motor Speedway (IMS) continued its tradition of releasing balloons before the start of the Indianapolis 500. The IMS claims that its balloons are biodegradable. However, studies conducted to test these claims still raise a big question and pose a substantial environmental risk.
Then, in 2022, the IMS management confirmed that the pre-race “Balloon Launch” has been paused indefinitely.
Regardless of what the Indy 500 does, several people and organizations still do balloon releases. Here are some reasons they harm the environment and potential alternatives to flying balloons.
Balloons are bad for wildlife and marine ecosystems.
The National Oceanic and Atmospheric Administration (NOAA) emphasizes that wildlife can confuse a balloon’s small, bright pieces as food. The agency points out that the balloons released into the air don’t merely go away. They either get stuck on something like electrical wires or tree branches. Others may deflate and plummet into the ground, where they can create many problems.
Balloons that are not disposed of properly end up in the ocean and along the shores, and worse, they can be mistaken for food by wildlife and marine animals. Strings or ribbons attached to the balloon, on the other hand, can cause entanglement and other injuries.
Another major problem is marine debris.
Experts are also worried about balloons becoming marine debris. Solid waste, found in global water bodies and the accumulation of such waste along waterway shorelines, is termed marine debris. Marine debris is frequently cited as one of the most widespread issues in global marine pollution.
7 Alternatives to Balloon Releases
At first, we are hesitant to talk about this because we know how sentimental balloon releases are in many communities, organizations, and families. Fortunately, there are several alternatives to balloon launches.
A non-profit organization called Clearwater Marine Aquarium recommends seven potential alternatives to balloon launches, including the following:
- Flags
- Banners
- Streamers
- Kites
- Pinwheels
- Bubbles
- Floating Flowers
Do you want to make a meaningful contribution to save Mother Nature? Now is the best opportunity to help! Next time you’re thinking about celebrating, try these environmentally friendly replacements for balloons.
Conclusion
Our effort has exposed the environmental hazard that balloon celebration may bring to our plant. We must reassess our traditions and consider some eco-friendly alternatives to commemorate special events. Let us prioritize sustainability and make informed choices to make a lasting impact on the environment. It’s time to deflate the myths and rise above the challenges associated with balloon releases.